تمام! يبقى هجهّز لك سكريبت تفصيلي جدًا بأسلوب تعليمي جامعي، طويل (~6–7 دقائق)، مع 3D visuals لكل مرحلة، ونبرة Voice Over رسمية وعلمية، عن Host–Virus Interaction: Avian Influenza Virus. هعمله مشهد بمشهد، مع نص جاهز للفويس أوفر بحيث تقدري تدخلينه مباشرة في أي AI Video Generator. --- 🎬 Extended Script – Avian Influenza Virus Host Interaction (University-Level Educational) Scene 1: Introduction Visuals: 3D zoom into avian respiratory epithelial cells; animation of multiple influenza viruses approaching the cells. Voice Over: "Avian influenza virus, a member of the Orthomyxoviridae family, causes highly contagious infections in birds and can occasionally infect humans. Understanding its interaction with host cells is crucial for developing antiviral strategies and vaccines. In this video, we explore the detailed mechanisms of viral entry, replication, and host response." --- Scene 2: Virus Structure Visuals: Rotating 3D model of influenza virus, highlighting Hemagglutinin (HA), Neuraminidase (NA), Matrix protein (M1), and viral RNA segments. Voice Over: "The virus is enveloped, with surface glycoproteins Hemagglutinin (HA) and Neuraminidase (NA) embedded in the lipid bilayer. HA mediates binding to host receptors, while NA facilitates viral release. Beneath the envelope lies the Matrix protein (M1) providing structural integrity, and the viral ribonucleoproteins (vRNPs) containing segmented RNA genomes necessary for replication." --- Scene 3: Attachment Visuals: HA molecules binding sialic acid receptors; different receptor types (α2,3 vs α2,6 linked sialic acids). Voice Over: "The first step of infection is attachment. HA recognizes and binds to sialic acid residues on host cell surfaces. Avian influenza preferentially binds α2,3-linked sialic acids, abundant in avian respiratory and intestinal epithelial cells, dictating host specificity." --- Scene 4: Entry via Endocytosis Visuals: Virus being engulfed by the cell membrane forming an endosome; acidification inside the vesicle; HA conformational change. Voice Over: "Following attachment, the virus is internalized through receptor-mediated endocytosis, forming an endosome. Acidification triggers HA conformational changes, enabling fusion of the viral envelope with the endosomal membrane, releasing viral RNA into the cytoplasm." --- Scene 5: Nuclear Transport Visuals: Viral RNPs moving along microtubules towards the nucleus; nuclear pore complex interaction. Voice Over: "The viral ribonucleoproteins are transported to the nucleus using the host cytoskeleton. They pass through nuclear pore complexes, where transcription and replication of viral RNA occur—an unusual feature for RNA viruses, highlighting influenza's dependence on nuclear machinery." --- Scene 6: Replication and Transcription Visuals: Viral RNA replication inside the nucleus; viral polymerase complex in action; synthesis of mRNA and cRNA. Voice Over: "Inside the nucleus, viral RNA-dependent RNA polymerase transcribes viral mRNA from the negative-sense RNA genome. Complementary RNA (cRNA) serves as a template for genome replication. These processes are tightly regulated to maximize viral protein production while avoiding detection by host sensors." --- Scene 7: Translation and Protein Trafficking Visuals: Viral mRNAs exiting the nucleus; translation in ribosomes; trafficking of HA and NA to the cell membrane. Voice Over: "Transcribed viral mRNAs are exported to the cytoplasm for translation. HA and NA proteins are synthesized in the endoplasmic reticulum, glycosylated, and transported to the plasma membrane. Structural proteins and vRNPs assemble near the membrane, preparing for viral budding." --- Scene 8: Assembly and Budding Visuals: Formation of new virions at the cell surface; NA cleaving sialic acids for release; virion detachment. Voice Over: "Viral components assemble at the host plasma membrane. NA activity cleaves sialic acid residues to prevent self-aggregation, facilitating the release of newly formed virions. These particles are then free to infect adjacent cells, perpetuating the infection cycle." --- Scene 9: Host Immune Response Visuals: Host immune cells recognizing viral infection; interferon signaling; cytokine storm illustration. Voice Over: "The host immune system recognizes viral RNA through pattern recognition receptors, inducing type I interferons and pro-inflammatory cytokines. However, avian influenza viruses have evolved mechanisms, such as NS1 protein-mediated interferon antagonism, to evade immune detection, allowing efficient replication." --- Scene 10: Clinical Relevance and Conclusion Visuals: Overview of virus lifecycle; vaccinated vs unvaccinated host cells; protective antibodies illustration. Voice Over: "Understanding the detailed interaction between avian influenza virus and host cells is essential for antiviral drug design, vaccine development, and controlling outbreaks. Comprehensive knowledge of viral entry, replication, and immune evasion informs strategies to protect both poultry and human populations." --- ✅ ملاحظات للاستخدام في AI Video Generator: كل مشهد 20–30 ثانية → الفيديو النهائي ~6–7 دقائق. Voice Over: English, formal educational tone. 3D animations: HA, NA, vRNP, endosome, nucleus transport. يمكن إضافة labels للمكونات الرئيسية: HA, NA, vRNP, M1, cytokines. --- لو تحبي، أقدر أجهز نسخة جاهزة للنسخ مباشرة في Invideo AI أو CapCut لكل مشهد مع مدة زمنية مقترحة بالثانية لكل مشهد، بحيث الفيديو يطلع احترافي طويل بدون أي تعديل إضافي. تحبي أعملها لك؟